What is Sitagliptin? Full information, usage, benefits and side effects

What is Sitagliptin? Full information, usage, benefits and side effects

Sitagliptin is an oral antidiabetic medication classified as a dipeptidyl peptidase-4 (DPP-4) inhibitor. It is commonly prescribed to manage blood sugar levels in individuals with type 2 diabetes.

Uses of Sitagliptin:

Sitagliptin is primarily used to:

  • Type 2 Diabetes Management: Improve glycemic control by increasing the levels of incretin hormones, which stimulate insulin release and reduce glucose production.

How Sitagliptin Works:

Sitagliptin works by inhibiting the activity of the DPP-4 enzyme, which usually breaks down incretin hormones. By inhibiting DPP-4, Sitagliptin prolongs the action of incretins, leading to increased insulin release and decreased glucagon production.

Benefits of Sitagliptin:

  • Blood Sugar Control: Helps lower and regulate blood sugar levels in individuals with type 2 diabetes.
  • Weight-Neutral: Typically does not cause significant weight gain, making it a favorable option for some individuals.

Dosage and Administration:

  • Dosage varies based on individual needs, response, and other factors.
  • Sitagliptin is available in tablet form, usually taken once daily.
  • Follow the prescribed dosage and instructions provided by healthcare professionals.

Side Effects of Sitagliptin:

While generally well-tolerated, Sitagliptin may cause side effects, including:

  • Common effects: Upper respiratory tract infections, headache, and nasopharyngitis.
  • Less common effects: Pancreatitis, hypersensitivity reactions, and joint pain.
  • Report any severe or persistent side effects to a healthcare professional.

Precautions:

  • Inform healthcare providers about existing medical conditions or medications.
  • Use caution in individuals with a history of pancreatitis or kidney problems.
  • Regular monitoring of blood sugar levels is essential during treatment.

Interactions:

  • Sitagliptin may interact with certain medications, including some antifungal drugs and certain antibiotics.
  • Inform healthcare providers about all over-the-counter and prescription medications being taken.

Warnings:

  • Sitagliptin should not be used in individuals with type 1 diabetes or diabetic ketoacidosis.
  • Hypersensitivity reactions, including severe skin reactions, have been reported. Seek medical attention if such reactions occur.
  • Inform healthcare providers if there are signs of pancreatitis, such as persistent severe abdominal pain.

It's important to note that this information is general, and specific details can vary. Always consult with a healthcare professional for personalized advice before using Sitagliptin or any medication.

References:

Author: Nikita Vishnoi BCA

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