What is Fenofibrate? Full information, usage, benefits and side effects

What is Fenofibrate? Full information, usage, benefits and side effects

Fenofibrate is a medication classified as a fibric acid derivative, commonly prescribed to lower cholesterol levels and triglycerides in the blood. It belongs to a class of drugs known as fibrates and is particularly effective in managing lipid disorders, including hypertriglyceridemia and mixed dyslipidemia.

Uses of Fenofibrate:

Fenofibrate is primarily used for:

  • Hypertriglyceridemia Treatment: Lowering elevated levels of triglycerides.
  • Mixed Dyslipidemia Treatment: Improving the lipid profile by lowering triglycerides and increasing high-density lipoprotein (HDL) cholesterol.

How Fenofibrate Works:

Fenofibrate works by activating the peroxisome proliferator-activated receptor alpha (PPAR-α), a nuclear receptor that regulates lipid metabolism. This activation leads to increased lipolysis and elimination of triglyceride-rich particles from the blood.

Benefits of Fenofibrate:

  • Triglyceride Reduction: Effectively lowers elevated triglyceride levels.
  • Improved Lipid Profile: Helps raise HDL cholesterol levels while reducing triglycerides.

Dosage and Administration:

  • Dosage varies based on the specific lipid disorder, individual response, and other factors.
  • Fenofibrate is typically taken orally in the form of tablets or capsules.
  • Follow the prescribed dosage and instructions provided by healthcare professionals.
  • Take the medication with meals to enhance absorption.

Side Effects of Fenofibrate:

While generally well-tolerated, fenofibrate may cause side effects, including:

  • Common effects: Upset stomach, diarrhea, and abdominal pain.
  • Less common effects: Muscle pain, weakness, and liver function abnormalities.
  • Report any severe or persistent side effects to a healthcare professional.

Precautions:

  • Inform healthcare providers about existing medical conditions or medications.
  • Use caution in individuals with a history of liver or kidney problems.
  • Regular monitoring of liver function may be recommended.

Interactions:

  • Fenofibrate may interact with certain medications, including anticoagulants and other lipid-lowering drugs.
  • Inform healthcare providers about all over-the-counter and prescription medications being taken.

Warnings:

  • Increased risk of myopathy: Monitor for muscle pain or weakness, especially in combination with statins.
  • Liver function monitoring: Regularly assess liver function during treatment.

It's important to note that this information is general, and specific details can vary. Always consult with a healthcare professional for personalized advice before using Fenofibrate or any medication.

References:


Author: Nikita Vishnoi BCA
Reviewed by: Dr. Sumitra Satsangi

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