Fenofibrate is a medication classified as a fibric acid derivative, commonly prescribed to lower cholesterol levels and triglycerides in the blood. It belongs to a class of drugs known as fibrates and is particularly effective in managing lipid disorders, including hypertriglyceridemia and mixed dyslipidemia.
Uses of Fenofibrate:
Fenofibrate is primarily used for:
- Hypertriglyceridemia Treatment: Lowering elevated levels of triglycerides.
- Mixed Dyslipidemia Treatment: Improving the lipid profile by lowering triglycerides and increasing high-density lipoprotein (HDL) cholesterol.
How Fenofibrate Works:
Fenofibrate works by activating the peroxisome proliferator-activated receptor alpha (PPAR-α), a nuclear receptor that regulates lipid metabolism. This activation leads to increased lipolysis and elimination of triglyceride-rich particles from the blood.
Benefits of Fenofibrate:
- Triglyceride Reduction: Effectively lowers elevated triglyceride levels.
- Improved Lipid Profile: Helps raise HDL cholesterol levels while reducing triglycerides.
Dosage and Administration:
- Dosage varies based on the specific lipid disorder, individual response, and other factors.
- Fenofibrate is typically taken orally in the form of tablets or capsules.
- Follow the prescribed dosage and instructions provided by healthcare professionals.
- Take the medication with meals to enhance absorption.
Side Effects of Fenofibrate:
While generally well-tolerated, fenofibrate may cause side effects, including:
- Common effects: Upset stomach, diarrhea, and abdominal pain.
- Less common effects: Muscle pain, weakness, and liver function abnormalities.
- Report any severe or persistent side effects to a healthcare professional.
Precautions:
- Inform healthcare providers about existing medical conditions or medications.
- Use caution in individuals with a history of liver or kidney problems.
- Regular monitoring of liver function may be recommended.
Interactions:
- Fenofibrate may interact with certain medications, including anticoagulants and other lipid-lowering drugs.
- Inform healthcare providers about all over-the-counter and prescription medications being taken.
Warnings:
- Increased risk of myopathy: Monitor for muscle pain or weakness, especially in combination with statins.
- Liver function monitoring: Regularly assess liver function during treatment.
It's important to note that this information is general, and specific details can vary. Always consult with a healthcare professional for personalized advice before using Fenofibrate or any medication.
References:
- MedlinePlus - "Fenofibrate": medlineplus.gov/druginfo/meds/a601052.html
- Drugs.com - "Fenofibrate": www.drugs.com/fenofibrate.html
- RxList - "Fenofibrate": www.rxlist.com/fenofibrate-drug.htm
Author: Nikita Vishnoi BCA
Reviewed by: Dr. Sumitra Satsangi
